Cargando…

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway. By solving the crystal structure of the IL-1α/apta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Xiaoming, Gelinas, Amy D., von Carlowitz, Ira, Janjic, Nebojsa, Pyle, Anna Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634487/ https://www.ncbi.nlm.nih.gov/pubmed/28993621 http://dx.doi.org/10.1038/s41467-017-00864-2

Ejemplares similares

Selection of DNA aptamers with two modified bases
por: Gawande, Bharat N., et al.
Publicado: (2017)

Modified aptamers as reagents to characterize recombinant human erythropoietin products
por: Jankowski, Wojciech, et al.
Publicado: (2020)

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents
por: Rohloff, John C, et al.
Publicado: (2014)

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression
por: Malireddi, R.K. Subbarao, et al.
Publicado: (2022)

Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex
por: Tollenaere, Maxim A.X., et al.
Publicado: (2023)

Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries
por: Atasoy Karakas, Latife, et al.
Publicado: (2022)

Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents
por: Gelinas, Amy D., et al.
Publicado: (2023)

HIF-1α regulates IL-1β and IL-17 in sarcoidosis
por: Talreja, Jaya, et al.
Publicado: (2019)

Inhibition of Keratinocyte Differentiation by the Synergistic Effect of IL-17A, IL-22, IL-1α, TNFα and Oncostatin M
por: Rabeony, Hanitriniaina, et al.
Publicado: (2014)

Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
por: Lin, Emily, et al.
Publicado: (2019)

Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
por: Ainscough, Joseph S., et al.
Publicado: (2014)

Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
por: Zhou, Jianjie, et al.
Publicado: (2022)

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion
por: Horai, Reiko, et al.
Publicado: (1998)

IL4Rα and IL13Rα1 Are Involved in the Development of Human Gallbladder Cancer
por: Ahn, Sung Woo, et al.
Publicado: (2022)

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes
por: Tapia, Victor S., et al.
Publicado: (2019)

Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor Microenvironment
por: Voronov, Elena, et al.
Publicado: (2013)

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
por: Bertheloot, Damien, et al.
Publicado: (2017)

IL‐1RA suppresses esophageal cancer cell growth by blocking IL‐1α
por: Chen, Sui, et al.
Publicado: (2019)

Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
por: Strauss, Sebastian, et al.
Publicado: (2018)

Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2
por: Hao, Guohua, et al.
Publicado: (2019)

Fit for the Eye: Aptamers in Ocular Disorders
por: Drolet, Daniel W., et al.
Publicado: (2016)

Structural basis for high-affinity recognition of aflatoxin B1 by a DNA aptamer
por: Xu, Guohua, et al.
Publicado: (2023)

IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β
por: Lee, Hyejin, et al.
Publicado: (2018)

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity
por: Junttila, Ilkka S., et al.
Publicado: (2008)

IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media
por: Serban, Roxana, et al.
Publicado: (2021)

IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice
por: Terlizzi, Michela, et al.
Publicado: (2016)

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
por: Neves, Fabiana, et al.
Publicado: (2015)

Identification of Inflammatory and Regulatory Cytokines IL-1α-, IL-4-, IL-6-, IL-12-, IL-13-, IL-17A-, TNF-α-, and IFN-γ-Producing Cells in the Milk of Dairy Cows with Subclinical and Clinical Mastitis
por: Vitenberga-Verza, Zane, et al.
Publicado: (2022)

Eccrine Sweat Contains IL-1α, IL-1β and IL-31 and Activates Epidermal Keratinocytes as a Danger Signal
por: Dai, Xiuju, et al.
Publicado: (2013)

Effect of the combination of the proinflammatory cytokines IL-1, tumor necrosis factor-α and IL-17
por: Miossec, P, et al.
Publicado: (2003)

IL-6 Induction by TNFα and IL-1β in an Osteoblast-Like Cell Line
por: Confalone, Elena, et al.
Publicado: (2010)

Expression of IL-1α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer
por: Song, Zhiwang, et al.
Publicado: (2016)

In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1β, TNFα, IL-6, IL-8, IL-10, MIP-1α, and MMP-9 in pre-labor human term placenta
por: Garcia-Ruíz, G., et al.
Publicado: (2015)

Endothelin-1 stimulates human monocytes in vitro to release TNF-α , IL-1β and IL-6
por: Helset, E., et al.
Publicado: (1993)

Epinephrine stimulates CXCL1 IL‐1α, IL‐6 secretion in isolated mouse limb muscle
por: Mattingly, Alex J., et al.
Publicado: (2017)

SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses
por: Lukens, John R, et al.
Publicado: (2014)

IL-36α Exerts Proinflammatory Effects in Aspergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB
por: Niu, Yawen, et al.
Publicado: (2021)

Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs
por: Patial, Sonika, et al.
Publicado: (2021)

IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity
por: Rauch, Daniel A, et al.
Publicado: (2014)

IL-15 Deficient Tax Mice Reveal a Role for IL-1α in Tumor Immunity
por: Rauch, Daniel A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_r1f50q8mu6rnjupcmbklg5bpjj