Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity

Ubiquitin ligase TRAF6, together with ubiquitin-conjugating enzyme Ubc13/Uev1, catalyzes processive assembly of unanchored K63-linked polyubiquitin chains for TAK1 activation in the IL-1R/TLR pathways. However, what domain and how it functions to enable TRAF6’s processivity are largely uncharacteriz...

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Detalles Bibliográficos
Autores principales: Hu, Lin, Xu, Jiafeng, Xie, Xiaomei, Zhou, Yiwen, Tao, Panfeng, Li, Haidong, Han, Xu, Wang, Chong, Liu, Jian, Xu, Pinglong, Neculai, Dante, Xia, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634496/
https://www.ncbi.nlm.nih.gov/pubmed/28993672
http://dx.doi.org/10.1038/s41467-017-01290-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634496/
https://www.ncbi.nlm.nih.gov/pubmed/28993672
http://dx.doi.org/10.1038/s41467-017-01290-0

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