Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance

Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense agai...

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Detalles Bibliográficos
Autores principales: Itakura, Junya, Sato, Miwa, Ito, Toshihiro, Mino, Megumi, Fushimi, Soichiro, Takahashi, Sakuma, Yoshimura, Teizo, Matsukawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634500/
https://www.ncbi.nlm.nih.gov/pubmed/28993690
http://dx.doi.org/10.1038/s41598-017-13204-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634500/
https://www.ncbi.nlm.nih.gov/pubmed/28993690
http://dx.doi.org/10.1038/s41598-017-13204-7

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