Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property

PARP1 trapping at DNA lesion by pharmacological inhibitors has been exploited in several cancers exhibiting defects in DNA repair mechanisms. PARP1 hyperactivation is involved in therapeutic resistance in multiple cancers. The role of PARP1 in cervical cancer (CC) resistance and implication of PARP...

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Detalles Bibliográficos
Autores principales: Prasad, Chandra Bhushan, Prasad, Shyam Babu, Yadav, Suresh Singh, Pandey, Laxmi Kant, Singh, Sunita, Pradhan, Satyajit, Narayan, Gopeshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634505/
https://www.ncbi.nlm.nih.gov/pubmed/28993682
http://dx.doi.org/10.1038/s41598-017-13232-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634505/
https://www.ncbi.nlm.nih.gov/pubmed/28993682
http://dx.doi.org/10.1038/s41598-017-13232-3

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