The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development

OBJECTIVE: Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intimal hyperplasia development. We studied the contrib...

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Detalles Bibliográficos
Autores principales: de Jong, Rob C. M., Ewing, Mark M., de Vries, Margreet R., Karper, Jacco C., Bastiaansen, Antonius J. N. M., Peters, Hendrika A. B., Baghana, Fabiana, van den Elsen, Peter J., Gongora, Céline, Jukema, J. Wouter, Quax, Paul H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634597/
https://www.ncbi.nlm.nih.gov/pubmed/29016683
http://dx.doi.org/10.1371/journal.pone.0185820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634597/
https://www.ncbi.nlm.nih.gov/pubmed/29016683
http://dx.doi.org/10.1371/journal.pone.0185820

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