Fixed Dosing of Monoclonal Antibodies in Oncology

Most monoclonal antibodies in oncology are administered in body–size‐based dosing schedules. This is believed to correct for variability in both drug distribution and elimination between patients. However, monoclonal antibodies typically distribute to the blood plasma and extracellular fluids only,...

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Detalles Bibliográficos
Autores principales: Hendrikx, Jeroen J.M.A., Haanen, John B.A.G., Voest, Emile E., Schellens, Jan H.M., Huitema, Alwin D.R., Beijnen, Jos H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2017
Materias:
New Drug Development and Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634778/
https://www.ncbi.nlm.nih.gov/pubmed/28754722
http://dx.doi.org/10.1634/theoncologist.2017-0167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634778/
https://www.ncbi.nlm.nih.gov/pubmed/28754722
http://dx.doi.org/10.1634/theoncologist.2017-0167

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