Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation. E3 ligases are gaining importance as targets to small molecules, both for direct inhibition and to be hijacked to induce the degradat...

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Detalles Bibliográficos
Autores principales: Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635026/
https://www.ncbi.nlm.nih.gov/pubmed/29018234
http://dx.doi.org/10.1038/s41467-017-00954-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635026/
https://www.ncbi.nlm.nih.gov/pubmed/29018234
http://dx.doi.org/10.1038/s41467-017-00954-1

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