Cargando…
Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells
The angelicin analogue 4,6,4′-trimethylangelicin (TMA) was recently reported as a strong inhibitor of nuclear factor-κB (NF-κB) activity and of the expression of the interleukin-8 (IL-8) gene in bronchial epithelial cells in which the inflammatory response has been challenged with P. aeruginosa, the...
Autores principales: | Lampronti, Ilaria, Manzione, Maria Giulia, Sacchetti, Gianni, Ferrari, Davide, Spisani, Susanna, Bezzerri, Valentino, Finotti, Alessia, Borgatti, Monica, Dechecchi, Maria Cristina, Miolo, Giorgia, Marzaro, Giovanni, Cabrini, Giulio, Gambari, Roberto, Chilin, Adriana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635289/ https://www.ncbi.nlm.nih.gov/pubmed/29089668 http://dx.doi.org/10.1155/2017/2389487 |
Ejemplares similares
-
New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease
por: Tupini, Chiara, et al.
Publicado: (2022) -
Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3–1 cells: Recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene
por: Finotti, Alessia, et al.
Publicado: (2012) -
Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression
por: Piccagli, Laura, et al.
Publicado: (2008) -
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
por: Vaccarin, Christian, et al.
Publicado: (2022) -
Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators
por: Laselva, Onofrio, et al.
Publicado: (2018)