Prostaglandin E(2) Inhibits Histamine-Evoked Ca(2+) Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A

In human aortic smooth muscle cells, prostaglandin E(2) (PGE(2)) stimulates adenylyl cyclase (AC) and attenuates the increase in intracellular free Ca(2+) concentration evoked by activation of histamine H(1) receptors. The mechanisms are not resolved. We show that cAMP mediates inhibition of histami...

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Detalles Bibliográficos
Autores principales: Taylor, Emily J. A., Pantazaka, Evangelia, Shelley, Kathryn L., Taylor, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635517/
https://www.ncbi.nlm.nih.gov/pubmed/28877931
http://dx.doi.org/10.1124/mol.117.109249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635517/
https://www.ncbi.nlm.nih.gov/pubmed/28877931
http://dx.doi.org/10.1124/mol.117.109249

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