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Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometal...

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Detalles Bibliográficos
Autores principales: Rojas, Anthony J., Zhang, Chi, Vinogradova, Ekaterina V., Buchwald, Nathan H., Reilly, John, Pentelute, Bradley L., Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635729/
https://www.ncbi.nlm.nih.gov/pubmed/29081961
http://dx.doi.org/10.1039/c6sc05454d