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Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis

Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes febrile chikungunya fever (CHIKF) in humans. This disease is debilitating and characterized by acute fever onset and chronic incapacitating polyarthralgia. CHIKF pathogenesis remains poorly defined with no approved vaccines and t...

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Autores principales: Chan, Yi-Hao, Lum, Fok-Moon, Ng, Lisa F. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635755/
https://www.ncbi.nlm.nih.gov/pubmed/29083392
http://dx.doi.org/10.3390/medsci3030064
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author Chan, Yi-Hao
Lum, Fok-Moon
Ng, Lisa F. P.
author_facet Chan, Yi-Hao
Lum, Fok-Moon
Ng, Lisa F. P.
author_sort Chan, Yi-Hao
collection PubMed
description Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes febrile chikungunya fever (CHIKF) in humans. This disease is debilitating and characterized by acute fever onset and chronic incapacitating polyarthralgia. CHIKF pathogenesis remains poorly defined with no approved vaccines and therapies. Recent outbreaks in the Caribbean islands have elevated concerns over the possibility of a global pandemic. Tremendous efforts have been made to develop relevant mouse models to enable the study of infection and immunity against this viral disease. Among them, the more common C57BL/6 mouse model demonstrated the ability to recapitulate the symptoms shown in infected humans, including self-limiting arthritis, myositis, and tenosynovitis. This has facilitated the unraveling of some key factors involved in disease pathogenesis of CHIKF. However, the stark differences in immune response between humans and mouse models necessitate the development of an animal model with an immune system that is more genetically similar to the human system for a better representation. In this paper, we aim to uncover the limitations of the C57BL/6 model and discuss alternative mouse models for CHIKV research.
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spelling pubmed-56357552017-10-26 Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis Chan, Yi-Hao Lum, Fok-Moon Ng, Lisa F. P. Med Sci (Basel) Review Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes febrile chikungunya fever (CHIKF) in humans. This disease is debilitating and characterized by acute fever onset and chronic incapacitating polyarthralgia. CHIKF pathogenesis remains poorly defined with no approved vaccines and therapies. Recent outbreaks in the Caribbean islands have elevated concerns over the possibility of a global pandemic. Tremendous efforts have been made to develop relevant mouse models to enable the study of infection and immunity against this viral disease. Among them, the more common C57BL/6 mouse model demonstrated the ability to recapitulate the symptoms shown in infected humans, including self-limiting arthritis, myositis, and tenosynovitis. This has facilitated the unraveling of some key factors involved in disease pathogenesis of CHIKF. However, the stark differences in immune response between humans and mouse models necessitate the development of an animal model with an immune system that is more genetically similar to the human system for a better representation. In this paper, we aim to uncover the limitations of the C57BL/6 model and discuss alternative mouse models for CHIKV research. MDPI 2015-08-07 /pmc/articles/PMC5635755/ /pubmed/29083392 http://dx.doi.org/10.3390/medsci3030064 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chan, Yi-Hao
Lum, Fok-Moon
Ng, Lisa F. P.
Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title_full Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title_fullStr Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title_full_unstemmed Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title_short Limitations of Current in Vivo Mouse Models for the Study of Chikungunya Virus Pathogenesis
title_sort limitations of current in vivo mouse models for the study of chikungunya virus pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635755/
https://www.ncbi.nlm.nih.gov/pubmed/29083392
http://dx.doi.org/10.3390/medsci3030064
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