Effects of the ABCB1 (1199G > A) Polymorphism on Steroid Sex Hormone-Induced P-Glycoprotein Expression, ATPase Activity, and Hormone Efflux

This study examined how the 1199G > A polymorphism in the ABCB1 gene encoding P-glycoprotein (P-gp) affects the protein’s expression, ATPase activity, and ability to pump female steroid sex hormones out of LLC-PK1 cells. The ABCB1 (1199G) or ABCB1 (1199A) allele was transfected into cells, which...

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Detalles Bibliográficos
Autores principales: Peng, Rui, Zhang, Hong, Zhang, Ying, Wei, Dan-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635765/
https://www.ncbi.nlm.nih.gov/pubmed/29083397
http://dx.doi.org/10.3390/medsci3040124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635765/
https://www.ncbi.nlm.nih.gov/pubmed/29083397
http://dx.doi.org/10.3390/medsci3040124

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