Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We her...

Descripción completa

Detalles Bibliográficos
Autores principales: Leitman, Ellen M., Palmer, Christine D., Buus, Søren, Chen, Fabian, Riddell, Lynn, Sims, Stuart, Klenerman, Paul, Sáez-Cirión, Asier, Walker, Bruce D., Hess, Paul R., Altfeld, Marcus, Matthews, Philippa C., Goulder, Philip J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636067/
https://www.ncbi.nlm.nih.gov/pubmed/29020090
http://dx.doi.org/10.1371/journal.pone.0184496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636067/
https://www.ncbi.nlm.nih.gov/pubmed/29020090
http://dx.doi.org/10.1371/journal.pone.0184496

Ejemplares similares