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Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We her...

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Detalles Bibliográficos
Autores principales:	Leitman, Ellen M., Palmer, Christine D., Buus, Søren, Chen, Fabian, Riddell, Lynn, Sims, Stuart, Klenerman, Paul, Sáez-Cirión, Asier, Walker, Bruce D., Hess, Paul R., Altfeld, Marcus, Matthews, Philippa C., Goulder, Philip J. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636067/ https://www.ncbi.nlm.nih.gov/pubmed/29020090 http://dx.doi.org/10.1371/journal.pone.0184496

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