Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs

Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted for antiviral drug development. In this study, we characterized the activity of recombinan...

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Detalles Bibliográficos
Autores principales: Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E., Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636120/
https://www.ncbi.nlm.nih.gov/pubmed/29020100
http://dx.doi.org/10.1371/journal.pone.0185998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636120/
https://www.ncbi.nlm.nih.gov/pubmed/29020100
http://dx.doi.org/10.1371/journal.pone.0185998

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