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Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking
The slow delayed-rectifier potassium current (I(Ks)) is crucial for human cardiac action potential repolarization. The formation of I(Ks) requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636153/ https://www.ncbi.nlm.nih.gov/pubmed/29020060 http://dx.doi.org/10.1371/journal.pone.0186293 |