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Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking

The slow delayed-rectifier potassium current (I(Ks)) is crucial for human cardiac action potential repolarization. The formation of I(Ks) requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5,...

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Detalles Bibliográficos
Autores principales:	Royal, Alice A., Tinker, Andrew, Harmer, Stephen C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636153/ https://www.ncbi.nlm.nih.gov/pubmed/29020060 http://dx.doi.org/10.1371/journal.pone.0186293

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