Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation

Cells adjust to hypoxic stress within the tumor microenvironment by downregulating energy-consuming processes including translation. To delineate mechanisms of cellular adaptation to hypoxia, we performed RNA-Seq of normoxic and hypoxic head and neck cancer cells. These data revealed a significant d...

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Detalles Bibliográficos
Autores principales: Brady, Lauren K., Wang, Hejia, Radens, Caleb M., Bi, Yue, Radovich, Milan, Maity, Amit, Ivan, Cristina, Ivan, Mircea, Barash, Yoseph, Koumenis, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636171/
https://www.ncbi.nlm.nih.gov/pubmed/28961236
http://dx.doi.org/10.1371/journal.pbio.2002623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636171/
https://www.ncbi.nlm.nih.gov/pubmed/28961236
http://dx.doi.org/10.1371/journal.pbio.2002623

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