A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition

When the immune system responds to tumour development, patterns of immune infiltrates emerge, highlighted by the expression of immune checkpoint-related molecules such as PDL1 on the surface of cancer cells. Such spatial heterogeneity carries information on intrinsic characteristics of the tumour le...

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Detalles Bibliográficos
Autores principales: Gong, Chang, Milberg, Oleg, Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Life Sciences–Mathematics interface
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636269/
https://www.ncbi.nlm.nih.gov/pubmed/28931635
http://dx.doi.org/10.1098/rsif.2017.0320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636269/
https://www.ncbi.nlm.nih.gov/pubmed/28931635
http://dx.doi.org/10.1098/rsif.2017.0320

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