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Molecular determinants of permeation in a fluoride-specific ion channel

Fluoride ion channels of the Fluc family combat toxicity arising from accumulation of environmental F(-). Although crystal structures are known, the densely packed pore region has precluded delineation of the ion pathway. Here we chart out the Fluc pore and characterize its chemical requirements for...

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Detalles Bibliográficos
Autores principales: Last, Nicholas B, Sun, Senmiao, Pham, Minh C, Miller, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636608/
https://www.ncbi.nlm.nih.gov/pubmed/28952925
http://dx.doi.org/10.7554/eLife.31259