The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons

The G-quadruplex is a non-canonical DNA secondary structure formed by four DNA strands containing multiple runs of guanines. G-quadruplexes play important roles in DNA recombination, replication, telomere maintenance, and regulation of transcription. Small molecules that stabilize the G-quadruplexes...

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Detalles Bibliográficos
Autores principales: Moruno-Manchon, Jose F., Koellhoffer, Edward C., Gopakumar, Jayakrishnan, Hambarde, Shashank, Kim, Nayun, McCullough, Louise D., Tsvetkov, Andrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636668/
https://www.ncbi.nlm.nih.gov/pubmed/28904242
http://dx.doi.org/10.18632/aging.101282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636668/
https://www.ncbi.nlm.nih.gov/pubmed/28904242
http://dx.doi.org/10.18632/aging.101282

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