Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families

Signaling pathway modules are often encoded by several closely related paralogous genes that can have redundant roles and are therefore difficult to analyze by loss-of-function analysis. A typical example is the Wnt signaling pathway, which in mammals is mediated by 19 Wnt ligands that can bind to 1...

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Detalles Bibliográficos
Autores principales: Voloshanenko, Oksana, Gmach, Philipp, Winter, Jan, Kranz, Dominique, Boutros, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636703/
https://www.ncbi.nlm.nih.gov/pubmed/28733458
http://dx.doi.org/10.1096/fj.201700144R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636703/
https://www.ncbi.nlm.nih.gov/pubmed/28733458
http://dx.doi.org/10.1096/fj.201700144R

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