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Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
Signaling pathway modules are often encoded by several closely related paralogous genes that can have redundant roles and are therefore difficult to analyze by loss-of-function analysis. A typical example is the Wnt signaling pathway, which in mammals is mediated by 19 Wnt ligands that can bind to 1...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Federation of American Societies for Experimental Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636703/ https://www.ncbi.nlm.nih.gov/pubmed/28733458 http://dx.doi.org/10.1096/fj.201700144R |