Uncoupling Oncogene-Induced Senescence (OIS) and DNA Damage Response (DDR) triggered by DNA hyper-replication: lessons from primary mouse embryo astrocytes (MEA)

Oncogene-induced senescence (OIS) is a complex process, in which activation of oncogenic signals during early tumorigenesis results in a high degree of DNA replication stress. The ensuing response to the DNA damage produces a permanent G1 arrest that prevents unlimited cell proliferation and lessens...

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Detalles Bibliográficos
Autores principales: Seoane, Marcos, Costoya, José A., Arce, Víctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636792/
https://www.ncbi.nlm.nih.gov/pubmed/29021613
http://dx.doi.org/10.1038/s41598-017-13408-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636792/
https://www.ncbi.nlm.nih.gov/pubmed/29021613
http://dx.doi.org/10.1038/s41598-017-13408-x

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