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The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. Here we report the quaternary architecture of multi-domain retinoic acid...

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Detalles Bibliográficos
Autores principales: Chandra, Vikas, Wu, Dalei, Li, Sheng, Potluri, Nalini, Kim, Youngchang, Rastinejad, Fraydoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636793/
https://www.ncbi.nlm.nih.gov/pubmed/29021580
http://dx.doi.org/10.1038/s41467-017-00981-y