The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation

The renal sodium chloride cotransporter, NCC, in the distal convoluted tubule is important for maintaining body Na(+) and K(+) homeostasis. Endogenous NCC is highly ubiquitylated, but the role of individual ubiquitylation sites is not established. Here, we assessed the role of 10 ubiquitylation site...

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Detalles Bibliográficos
Autores principales: Rosenbaek, Lena L., Rizzo, Federica, Wu, Qi, Rojas-Vega, Lorena, Gamba, Gerardo, MacAulay, Nanna, Staub, Olivier, Fenton, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636807/
https://www.ncbi.nlm.nih.gov/pubmed/29021560
http://dx.doi.org/10.1038/s41598-017-12819-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636807/
https://www.ncbi.nlm.nih.gov/pubmed/29021560
http://dx.doi.org/10.1038/s41598-017-12819-0

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