Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses

IFN-γ-producing cytotoxic T lymphocytes are essential for host defense against viral infection and cancer. Here we show that the RNA-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+) T-cell production of IFN-γ in vivo. When activated in vitro, however, IFN-γ production by naive wild ty...

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Detalles Bibliográficos
Autores principales: Wang, Qinghong, Ning, Huan, Peng, Hui, Wei, Lin, Hou, Rong, Hoft, Daniel F., Liu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636828/
https://www.ncbi.nlm.nih.gov/pubmed/29021521
http://dx.doi.org/10.1038/s41467-017-00892-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636828/
https://www.ncbi.nlm.nih.gov/pubmed/29021521
http://dx.doi.org/10.1038/s41467-017-00892-y

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