Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer’s disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafis...

Descripción completa

Detalles Bibliográficos
Autores principales: Cosacak, Mehmet I., Bhattarai, Prabesh, Bocova, Ledio, Dzewas, Tim, Mashkaryan, Violeta, Papadimitriou, Christos, Brandt, Kerstin, Hollak, Heike, Antos, Christopher L., Kizil, Caghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636889/
https://www.ncbi.nlm.nih.gov/pubmed/29021554
http://dx.doi.org/10.1038/s41598-017-13311-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636889/
https://www.ncbi.nlm.nih.gov/pubmed/29021554
http://dx.doi.org/10.1038/s41598-017-13311-5

Ejemplares similares