Cargando…

Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer’s disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cosacak, Mehmet I., Bhattarai, Prabesh, Bocova, Ledio, Dzewas, Tim, Mashkaryan, Violeta, Papadimitriou, Christos, Brandt, Kerstin, Hollak, Heike, Antos, Christopher L., Kizil, Caghan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636889/ https://www.ncbi.nlm.nih.gov/pubmed/29021554 http://dx.doi.org/10.1038/s41598-017-13311-5

Ejemplares similares

Neural stem/progenitor cells in Alzheimer’s disease
por: Tincer, Gizem, et al.
Publicado: (2016)

Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease
por: Mold, Matthew John, et al.
Publicado: (2021)

Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
por: Dregni, Aurelio J., et al.
Publicado: (2022)

Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2019)

Protocol for Dissection and Dissociation of Zebrafish Telencephalon for Single-Cell Sequencing
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2020)

Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles
por: Hunter, Sally, et al.
Publicado: (2015)

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain
por: Bhattarai, Prabesh, et al.
Publicado: (2020)

Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia in vivo but Not in vitro
por: Mashkaryan, Violeta, et al.
Publicado: (2020)

Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease
por: Ono, Masahiro, et al.
Publicado: (2016)

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice
por: Bi, Mian, et al.
Publicado: (2011)

Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics
por: Metaxas, Athanasios, et al.
Publicado: (2016)

GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes
por: Celikkaya, Hilal, et al.
Publicado: (2019)

Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
por: Rafique, Waqas, et al.
Publicado: (2018)

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2021)

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles
por: Kaeser, Stephan A., et al.
Publicado: (2021)

Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer’s disease()
por: Stouffer, Kaitlin M., et al.
Publicado: (2023)

Is Alzheimer’s Also a Stem Cell Disease? – The Zebrafish Perspective
por: Kizil, Caghan, et al.
Publicado: (2018)

Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2015)

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
por: Jaworski, Tomasz, et al.
Publicado: (2009)

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
por: Ahmed, Zeshan, et al.
Publicado: (2014)

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
por: Qi, Yao, et al.
Publicado: (2020)

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2022)

The role of extracellular Tau in the spreading of neurofibrillary pathology
por: Medina, Miguel, et al.
Publicado: (2014)

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease
por: Miyashita, A, et al.
Publicado: (2014)

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
por: Hondius, David C., et al.
Publicado: (2021)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles
por: Xie, Ce, et al.
Publicado: (2014)

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
por: Bryan, Kathryn J, et al.
Publicado: (2008)

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease
por: Wang, Chunyu, et al.
Publicado: (2016)

In vivo quantification of neurofibrillary tangles with [(18)F]MK-6240
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer’s Disease
por: Siddiqui, Tohid, et al.
Publicado: (2021)

Clinical Neuropathology image 5-2016: neurofibrillary tangle-rich ganglioglioma
por: Gelpi, Ellen, et al.
Publicado: (2016)

Braak neurofibrillary tangle staging prediction from in vivo MRI metrics
por: Dallaire-Théroux, Caroline, et al.
Publicado: (2019)

Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment
por: Powell, W. Ryan, et al.
Publicado: (2022)

Tangled tau: Active pathology or footprint of disease?
por: Higham, James P.
Publicado: (2017)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n6alp9n9botna03n89f2mpq3t5