Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi

The formation of platelet thrombi is determined by the integrin αIIbβ3-mediated interactions of platelets with fibrinogen and fibrin. Blood clotting in vivo is catalyzed by thrombin, which simultaneously induces fibrinogen binding to αIIbβ3 and converts fibrinogen to fibrin. Thus, after a short time...

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Detalles Bibliográficos
Autores principales: Höök, Peter, Litvinov, Rustem I., Kim, Oleg V., Xu, Shixin, Xu, Zhiliang, Bennett, Joel S., Alber, Mark S., Weisel, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636895/
https://www.ncbi.nlm.nih.gov/pubmed/29021578
http://dx.doi.org/10.1038/s41598-017-12615-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636895/
https://www.ncbi.nlm.nih.gov/pubmed/29021578
http://dx.doi.org/10.1038/s41598-017-12615-w

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