Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age

The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activati...

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Detalles Bibliográficos
Autores principales: de Jong, Britt G, IJspeert, Hanna, Marques, Lemelinda, van der Burg, Mirjam, van Dongen, Jacques JM, Loos, Bruno G, van Zelm, Menno C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636940/
https://www.ncbi.nlm.nih.gov/pubmed/28546550
http://dx.doi.org/10.1038/icb.2017.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636940/
https://www.ncbi.nlm.nih.gov/pubmed/28546550
http://dx.doi.org/10.1038/icb.2017.43

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