Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation

Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B-cell and antibody deficiency (common variable immunodeficiency), inflammatory bowel disease, enlarged spleen and lymph nodes, accumulation of activated T...

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Detalles Bibliográficos
Autores principales: Burnett, Deborah L, Parish, Ian A, Masle-Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636941/
https://www.ncbi.nlm.nih.gov/pubmed/28611475
http://dx.doi.org/10.1038/icb.2017.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636941/
https://www.ncbi.nlm.nih.gov/pubmed/28611475
http://dx.doi.org/10.1038/icb.2017.50

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