Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, characterized by degeneration of dopaminergic neurons in the substantia nigra. α-synuclein (α-syn) and PTEN-induced putative kinase (PINK)1 are two critical proteins associated with the pathogenesis of PD. α-syn induces m...

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Detalles Bibliográficos
Autores principales: Liu, Jia, Wang, Xue, Lu, Yongquan, Duan, Chunli, Gao, Ge, Lu, Lingling, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636973/
https://www.ncbi.nlm.nih.gov/pubmed/28933786
http://dx.doi.org/10.1038/cddis.2017.427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636973/
https://www.ncbi.nlm.nih.gov/pubmed/28933786
http://dx.doi.org/10.1038/cddis.2017.427

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