Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis

The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level. Specifically, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Siyu, Juan, Jiaxiang, Zhang, Zubin, Du, Yanyun, Xu, Yujia, Tong, Jiefei, Cao, Biyin, Moran, Michael F, Zeng, Yuanying, Mao, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636991/
https://www.ncbi.nlm.nih.gov/pubmed/28933784
http://dx.doi.org/10.1038/cddis.2017.450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636991/
https://www.ncbi.nlm.nih.gov/pubmed/28933784
http://dx.doi.org/10.1038/cddis.2017.450

Ejemplares similares