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Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level. Specifically, the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636991/ https://www.ncbi.nlm.nih.gov/pubmed/28933784 http://dx.doi.org/10.1038/cddis.2017.450 |