Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner

BACKGROUND: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN in experimental animal models suggesting that...

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Detalles Bibliográficos
Autores principales: Waasdorp, Maaike, Duitman, JanWillem, Spek, C. Arnold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637235/
https://www.ncbi.nlm.nih.gov/pubmed/29114573
http://dx.doi.org/10.1016/j.bbrep.2017.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637235/
https://www.ncbi.nlm.nih.gov/pubmed/29114573
http://dx.doi.org/10.1016/j.bbrep.2017.03.009

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