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Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner
BACKGROUND: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN in experimental animal models suggesting that...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637235/ https://www.ncbi.nlm.nih.gov/pubmed/29114573 http://dx.doi.org/10.1016/j.bbrep.2017.03.009 |