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Effect of methotrexate/vitamin B(12) on DNA methylation as a potential factor in leukemia treatment-related neurotoxicity
Methotrexate (MTX) is administered to treat childhood acute lymphoblastic leukemia (ALL). It acts by inhibiting dihydrofolate reductase which reduces methyltetrahydrofolate, a key component in one carbon metabolism, thus reducing cell proliferation. Further perturbations to one carbon metabolism, su...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638018/ https://www.ncbi.nlm.nih.gov/pubmed/28809129 http://dx.doi.org/10.2217/epi-2016-0165 |