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Effect of methotrexate/vitamin B(12) on DNA methylation as a potential factor in leukemia treatment-related neurotoxicity

Methotrexate (MTX) is administered to treat childhood acute lymphoblastic leukemia (ALL). It acts by inhibiting dihydrofolate reductase which reduces methyltetrahydrofolate, a key component in one carbon metabolism, thus reducing cell proliferation. Further perturbations to one carbon metabolism, su...

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Detalles Bibliográficos
Autores principales:	Forster, Victoria J, McDonnell, Alex, Theobald, Rachel, McKay, Jill A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Medicine Ltd 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638018/ https://www.ncbi.nlm.nih.gov/pubmed/28809129 http://dx.doi.org/10.2217/epi-2016-0165

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