Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone

The frequency of stable DNA adducts in a target tissue can be used to assess biologically effective dose; however, the utility of the metric in a risk assessment context depends on the likelihood that the DNA damage will be manifested as mutation. Previously, we employed the Muta™Mouse system to exa...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Paul A, Douglas, George R, Phillips, David H, Arlt, Volker M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Manuscripts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638019/
https://www.ncbi.nlm.nih.gov/pubmed/28096451
http://dx.doi.org/10.1093/mutage/gew067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638019/
https://www.ncbi.nlm.nih.gov/pubmed/28096451
http://dx.doi.org/10.1093/mutage/gew067

Ejemplares similares