Ruthenium‐Catalyzed Azide–Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation

The development of efficient metal‐promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo efficient and regioselective room‐temperature annulations with thioalkynes in aqueous milieu when treated with catalytic amounts of a suitable ruthe...

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Detalles Bibliográficos
Autores principales: Destito, Paolo, Couceiro, José R., Faustino, Hélio, López, Fernando, Mascareñas, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638077/
https://www.ncbi.nlm.nih.gov/pubmed/28685950
http://dx.doi.org/10.1002/anie.201705006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638077/
https://www.ncbi.nlm.nih.gov/pubmed/28685950
http://dx.doi.org/10.1002/anie.201705006

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