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Ruthenium‐Catalyzed Azide–Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation

The development of efficient metal‐promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo efficient and regioselective room‐temperature annulations with thioalkynes in aqueous milieu when treated with catalytic amounts of a suitable ruthe...

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Detalles Bibliográficos
Autores principales:	Destito, Paolo, Couceiro, José R., Faustino, Hélio, López, Fernando, Mascareñas, José L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638077/ https://www.ncbi.nlm.nih.gov/pubmed/28685950 http://dx.doi.org/10.1002/anie.201705006

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