Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation

ESSENTIALS: Corn Trypsin Inhibitor (CTI) is a selective inhibitor of coagulation Factor XII (FXII). Molecular modelling of the CTI‐FXIIa complex suggested a canonical inhibitor binding mode. Mutagenesis revealed the CTI inhibitory loop and helices α1 and α2 mediate the interaction. This confirms tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamad, B. K., Pathak, M., Manna, R., Fischer, P. M., Emsley, J., Dekker, L. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
COAGULATION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638086/
https://www.ncbi.nlm.nih.gov/pubmed/28688220
http://dx.doi.org/10.1111/jth.13773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638086/
https://www.ncbi.nlm.nih.gov/pubmed/28688220
http://dx.doi.org/10.1111/jth.13773

Ejemplares similares