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Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation

ESSENTIALS: Corn Trypsin Inhibitor (CTI) is a selective inhibitor of coagulation Factor XII (FXII). Molecular modelling of the CTI‐FXIIa complex suggested a canonical inhibitor binding mode. Mutagenesis revealed the CTI inhibitory loop and helices α1 and α2 mediate the interaction. This confirms tha...

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Detalles Bibliográficos
Autores principales:	Hamad, B. K., Pathak, M., Manna, R., Fischer, P. M., Emsley, J., Dekker, L. V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	COAGULATION
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638086/ https://www.ncbi.nlm.nih.gov/pubmed/28688220 http://dx.doi.org/10.1111/jth.13773

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