Systematic, network-based characterization of therapeutic target inhibitors

A large fraction of the proteins that are being identified as key tumor dependencies represent poor pharmacological targets or lack clinically-relevant small-molecule inhibitors. Availability of fully generalizable approaches for the systematic and efficient prioritization of tumor-context specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Yao, Alvarez, Mariano J., Bisikirska, Brygida, Lachmann, Alexander, Realubit, Ronald, Pampou, Sergey, Coku, Jorida, Karan, Charles, Califano, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638208/
https://www.ncbi.nlm.nih.gov/pubmed/29023443
http://dx.doi.org/10.1371/journal.pcbi.1005599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638208/
https://www.ncbi.nlm.nih.gov/pubmed/29023443
http://dx.doi.org/10.1371/journal.pcbi.1005599

Ejemplares similares