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Identifying direct contacts between protein complex subunits from their conditional dependence in proteomics datasets

Determining the three dimensional arrangement of proteins in a complex is highly beneficial for uncovering mechanistic function and interpreting genetic variation in coding genes comprising protein complexes. There are several methods for determining co-complex interactions between proteins, among t...

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Detalles Bibliográficos
Autores principales: Drew, Kevin, Müller, Christian L., Bonneau, Richard, Marcotte, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638211/
https://www.ncbi.nlm.nih.gov/pubmed/29023445
http://dx.doi.org/10.1371/journal.pcbi.1005625