Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens

Small molecule screens are widely used to prioritize pharmaceutical development. However, determining the pathways targeted by these molecules is challenging, since the compounds are often promiscuous. We present a network strategy that takes into account the polypharmacology of small molecules in o...

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Detalles Bibliográficos
Autores principales: Ursu, Oana, Gosline, Sara J. C., Beeharry, Neil, Fink, Lauren, Bhattacharjee, Vikram, Huang, Shao-shan Carol, Zhou, Yan, Yen, Tim, Fraenkel, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638242/
https://www.ncbi.nlm.nih.gov/pubmed/29023490
http://dx.doi.org/10.1371/journal.pone.0185650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638242/
https://www.ncbi.nlm.nih.gov/pubmed/29023490
http://dx.doi.org/10.1371/journal.pone.0185650

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