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Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens
Small molecule screens are widely used to prioritize pharmaceutical development. However, determining the pathways targeted by these molecules is challenging, since the compounds are often promiscuous. We present a network strategy that takes into account the polypharmacology of small molecules in o...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638242/ https://www.ncbi.nlm.nih.gov/pubmed/29023490 http://dx.doi.org/10.1371/journal.pone.0185650 |