The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia

Notch is a major oncogenic driver in T cell acute lymphoblastic leukemia (T-ALL), in part because it binds to an enhancer that increases expression of MYC. Here, we exploit the capacity of activated NOTCH1 and NOTCH3 to induce T-ALL, despite substantial divergence in their intracellular regions, as...

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Detalles Bibliográficos
Autores principales: Choi, Sung Hee, Severson, Eric, Pear, Warren S., Liu, Xiaole S., Aster, Jon C., Blacklow, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296/
https://www.ncbi.nlm.nih.gov/pubmed/29023469
http://dx.doi.org/10.1371/journal.pone.0185762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296/
https://www.ncbi.nlm.nih.gov/pubmed/29023469
http://dx.doi.org/10.1371/journal.pone.0185762

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