Bcl-x(L) mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages

Virulent Mycobacterium tuberculosis (Mtb) triggers necrosis in host Mφ, which is essential for successful pathogenesis. Here we demonstrate that necrosis of Mtb-infected Mφ is dependent on the action of the cytosolic kinase Receptor Interacting Protein 3 (RIPK3) and the mitochondrial Bcl-2 family me...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaomin, Khan, Nargis, Gan, Huixian, Tzelepis, Fanny, Nishimura, Tomoyasu, Park, Seung-Yeol, Divangahi, Maziar, Remold, Heinz G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638669/
https://www.ncbi.nlm.nih.gov/pubmed/28401933
http://dx.doi.org/10.1038/mi.2017.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638669/
https://www.ncbi.nlm.nih.gov/pubmed/28401933
http://dx.doi.org/10.1038/mi.2017.12

Ejemplares similares